To determine whether restoration of Sod3 in the VEGF-C KD cells could rescue tumor progression, we injected luciferase labeled 66 cl4-scramble control, 66 cl4-VEGF-C KD and 66 cl4-VEGF-C Sod3 restored (VEGF-C KD + Sod3) cell lines into immunocompetent female BALB/c mice, and tumor growth and metastases were measured. This evidence concerns the gene SOD3 and neoplasm.