However, since Sod3 is not sufficient to fully rescue the in vivo tumor growth and/or metastasis in response to VEGF-C KD (Figure 6), nor is it sufficient to rescue chemoresistance after VEGF-C KD in vitro (Additional file 12: Figure S12), other pathways and/or factors downstream of VEGF-C must be required to fully restore these phenotypes. This evidence concerns the gene SOD3 and neoplasm.