ERVW-1 and infection: Upon analyzing the activity spectrum of HCV using HCVpp bearing envelope proteins from different HCV genotypes (1a, 1b, 2a, 2b, 4a and 6a), 281816 was found to inhibit the infection of all tested genotypes with IC50’s ranging from 2.2 μM to 4.6 μM (Table 5), indicating that this small molecule inhibits HCV infection in a genotype-independent manner.