In these experiments two kinds of plasmacytoma cells were injected into wild type mice: tumor cells that have been transfected with IL-35 (J558-IL-35) so that tumor secretes high amount of IL-35 into the microenvironment, and “normal” plasmacytoma cells (J558-Ctrl) that secrete very small amount of IL-35. The gene discussed is CTRL; the disease is plasmacytoma.