Of them, lncRNA-SENCR is found to be a vascular cell-enriched lncRNA, and its knockdown results in decreased expression of Myocardin and smooth muscle contractile genes.13 The knockdown of Ang II-regulated lncRNA, lnc-Ang362, affects the proliferation of vascular smooth muscle cells, suggesting a potential role in the diagnosis of Ang II-associated cardiovascular diseases.14 MALAT1 knockdown tips the balance from a proliferative to a migratory endothelial cell phenotype in vitro, and its genetic deletion or pharmacological inhibition could reduce vascular growth in vivo. The gene discussed is MALAT1; the disease is cardiovascular disorder.