Its expression is significantly upregulated in a wide range of tumors, such as lung cancer, liver cancer, renal cell carcinoma, bladder cancer, and osteosarcoma.19 Previous studies have revealed that MALAT1 has a positive role in tumor cell proliferation, apoptosis, migration, invasion, or the metastatic spread of tumor cells.20 Here, we found that MALAT1 knockdown results in a significant reduction in retinal endothelial cell proliferation, migration, and tube formation. Here, MALAT1 is linked to hereditary clear cell renal cell carcinoma.