CDKN2B-AS1 and type 2 diabetes mellitus: LncRNAs participate in a variety of biological processes, such as chromosome imprinting, epigenetic regulation, cell-cycle control, cell apoptosis, and reprogramming of induced pluripotent stem cells.6, 7 Recently, Human β cell transcriptome analysis indicates that lncRNAs are dynamically regulated and abnormally expressed in type 2 diabetes.8 GWAS study shows that lncRNA-ANRIL is significantly associated with increased susceptibility to type 2 diabetes.9 These evidences indicate that lncRNA is a potential regulator of DM pathogenesis.