Diabetes results in a marked increase in the expression of ICAM-1, VEGF, and TNF-α, whereas MALAT1 knockdown could significantly reduce the induction of VEGF, TNF-α, and ICAM-1 (Figure 4), suggesting that MALAT1 knockdown could alleviate retinal inflammation in diabetic rats. This evidence concerns the gene MALAT1 and diabetes mellitus.