15 CVD-associated lncRNA, ANRIL, have a critical role in atherosclerosis progression by modulating the expression of genes involved in cell proliferation, apoptosis, extra-cellular matrix remodeling, and inflammatory response.16 Our previous study reveals a potential link between MALAT1 and DR.10 In this study, we found that MALAT1 could activate p38/MAPK signaling pathway and regulate retinal endothelial cell function and pathological microvascular growth under diabetic condition. The gene discussed is MALAT1; the disease is atherosclerosis.