It has been demonstrated that functional p53 has an opposing effect in glioma treated with TMZ or nimustine (ACNU).4, 5 To extend these observations to cisplatin treatment, the cell sensitivity was evaluated in glioma cell lines with different p53 status: U87MG and U343MG (p53wt) and U251MG and U138MG (p53mt). Here, TP53 is linked to central nervous system cancer.