TP53 and central nervous system cancer: However, there are conflicting data concerning cisplatin treatment and p53 status in glioma cell lines.17, 18, 19 In our study, using four distinct cell lines, two with wild-type p53 and two with mutated p53, no correlation between p53 status and cisplatin cellular sensitivity was observed: the cell viability, as determined by XTT assays, and apoptosis (sub-G1) results revealed that U251MG cells (p53mt) are highly sensitive to cisplatin, in contrast to U138MG, which is also a p53 mutant cell line.