Our previous study showed the depletion of TLX in adult hippocampal progenitors increased active caspase-3, indicative of a prosurvival role for TLX in neural progenitors.11 As Akt is a well-known prosurvival signaling molecule and its activation is a marker for poor outcome and prognosis in NB,18 the levels of phosphorylated Akt were compared in WT cells before and after transient knockdown of TLX using shRNA. Here, AKT1 is linked to neuroblastoma.