Hypoxia is a well-known condition that induces epithelial-to-mesenchymal transition (EMT), a hallmark of the morphologic changes of tumor cells leading to metastases by various mechanisms.38 Interestingly, it has recently been proposed that Oct-4 expression can promote the migration and invasion of glioblastoma cells.39 It is an obvious possibility that TLX could be a critical factor by virtue of its dual role in matrix remodeling and angiogenesis, along with regulation of cell-cycle programs contributing to EMT. The gene discussed is NR2E1; the disease is glioblastoma.