NR2E1 and neoplasm: TLX is a neural cell-specific renewal factor, and gene amplification of TLX has been reported to occur in malignant glioma.13 By expressing TLX, the tumor cells appear to engage neurogenetic niches for their own maintenance.23 Here we demonstrate that TLX is also highly expressed in the stem cell-like population enriched from NB, originating from the sympathetic nervous system.