IARS1 and colorectal carcinoma: We therefore evaluated the cytotoxicity of A1-IRS in other cancer cell lines established from mammary gland ductal carcinoma (MDA), gastric adenocarcinoma (HGT1), cervix adenocarcinoma (HeLa), melanoma (Skmel), colorectal carcinoma (HCT116), chronic lymphocytic leukemia (JOK-1) and from adenovirus transformed epithelial embryonic kidney cells (HEK-293).