IL1R1 and airway hyperresponsiveness: In order to verify the action mechanism of NecroX-5, that is, whether or not the anti-asthmatic effect of NecroX-5 works via suppression of inflammasome activation, we evaluated the role of IL-1β on changes in BAL cells, histologic features, airway hyperresponsiveness and protein levels of pro-inflammatory cytokines using an anti-IL-1β-neutralizing antibody or IL-1R KO mice.