NLRP3 and allergic asthma: Conclusively, this study using both murine models of allergic asthma, that is, OVALPS-OVA mice and HDM-instilled mice suggests that mitochondrial ROS have a critical role in the pathogenesis of allergenic airway inflammation through the modulation of NLRP3 inflammasome activation, especially in bronchial epithelial cells as an immune responder, providing a novel concept of therapeutic strategy for allergen-induced airway disorders.