Cell death was alternatively also blocked by inclusion of necrosulfonamide (Figure 2f), which targets the death-inducing RIPK3 substrate, MLKL.18 These results, together, suggest that necroptosis is induced by activation of RIPK1 followed by activation of RIPK3 and MLKL in ovarian cancer cells. The gene discussed is RIPK3; the disease is ovarian carcinoma.