Our study revealed that UCN-01 treatment resulted in Puma induction in a variety of tumor cells, such as human colon cells (HCT116, HCT116 p53 KO, HT29 and DLD1), human ovarian cells (A2780/S and A2780/CP), leukemia cells (K562/S and K562/CP) and breast cancer cells (MCF-7 and MDA-MB-231) (Figure 1). This evidence concerns the gene TP53 and neoplasm.