To determine whether reconstitution of WWP2 expression in cancer cells resulted in reducing Notch3 signaling activity and subsequently cellular proliferation, we performed proliferation assays in OVCAR3 and MCF7 cells transduced with pLPC control plasmid, N3-ICD, WWP2, or catalytically inactive mutant WWP2-C838A (WWP2-CA). This evidence concerns the gene WWP2 and cancer.