SERPINE1 and neoplasm: Deficiency in PAI-1 reduced tumor cross-sectional area by 52% (p<0.05, Fig. 2b) and tumor volume by 61% (p<0.05, Fig. 2c) in high-fat fed mice, but the deficiency did not affect either cross-sectional area or volume in mice fed the AIN93G diet (Fig. 2b, 2c), compared to their respective wild-type controls.