Interestingly, we observed that the prevalence of the APOE ε2 allele in males was higher than that in females in both the hyperuricemic (11.3% vs. 8.8%) and normouricemic (6.7% vs. 4.8%) groups (Table 3), which may be another reason besides differences in sex hormones for the reduced renal excretion of uric acid and the high incidence of hyperuricemia in males. Here, APOE is linked to hyperuricemia.