HMGB1 and hepatocellular carcinoma: Figure 5 showed the result of a meta-analysis of hazard ratios (HR) of HMGB1 high expression and low expression in the survival of patients with HCC. The overall survival (OS) was significantly shorter in HCC patients with high HMGB1 expression compared those with low HMGB1 expression, and the pooled HR was 1.31 with 95% CI 1.20–1.44, (Z = 5.82, p<0.0001, heterogeneity I2 = 20%, Figure 5).