In fact, in tumor cells oxidative stress induces ADAM-9, -10, and -17 activity which results in cell-surface cleavage of pro-HB-EGF and subsequent EGFR transactivation [51] and adenosine triphosphate (ATP)-dependent activation of the purinergic receptor of the P2Y family of GPCRs stimulates TGFα proteolysis with concomitant EGFR activation, in both murine fibroblasts and Chinese hamster ovary (CHO) cells [49]. Here, EGFR is linked to neoplasm.