In kidney cancer cell lines, LPA-induced HB-EGF shedding and subsequent EGFR transactivation is mediated by ADAM10 in ACHN cells, whereas ADAM17 is responsible for these events in human renal carcinoma cells (CaKi2) and Human kidney carcinoma cell line (A498) [43]. The gene discussed is ADAM17; the disease is renal carcinoma.