We also assessed the association between the occurrence of KC and combined genotypes of the g.46438521G>C—NEIL1, c.2285T>C—PARP-1, c.–1370T>A—POLG, c.580C>T—XRCC1 and c.1196A>G—XRCC1 polymorphisms. The gene discussed is POLG; the disease is keratoconus.