APP and Alzheimer disease: Given the rationale and background outlined above, we first explored the expression of PDE III in postmortem human brains followed by a series of experiments using transgenic mice (Tg-SwDI mice) expressing the Swedish (K670/M671L) and vasculotropic Dutch/Iowa (E693Q/D694N) mutant of the human amyloid precursor protein (APP) to examine whether cilostazol protected against the disruption of the neurovascular unit and rescued the perivascular drainage of Aβ in AD/CAA.