CYP1A2 and posterior cortical atrophy: We also considered the role of polymorphisms in selected genes that code for tobacco carcinogens metabolism enzymes (GSTP1, PTGS2, CYP1A2, CYP2E1, EPHX1, CYP1B1, UGT1A6, NAT2, GSTM1, and GSTT1) as potential modifiers of the relationship between tobacco smoking and PCa risk.