CYP1A2 and posterior cortical atrophy: In this study, we found that the association between smoking status and PCa risk was modified by CYP1A2 -154A>C (rs762551), a gene that codes for an enzyme that plays a key role in the metabolism of many drugs, such as caffeine, and in the activation of various tobacco carcinogens, including HCAs and PAHs [38–42].