BDNF and injury: Here we report that BDNF binding to these presynaptic TrkB receptors produce both a transient depolarizing shift of EGABA and a reduction of GGABA in primary sensory neurons after nerve injury, leading to a transient presynaptic disinhibition and consequently to the development of thermal hypersensitivity, while postsynaptic disinhibition regulated by BDNF initiates static mechanical hypesensitivity.