VEGFA and neoplasm: When mice were supplemented with optimal levels of ascorbate, their tumor VEGF levels were significantly reduced (2.8 ± 0.4 and 5.4 ± 2.5 pg/μg DNA in B16-F10 and LL/2, respectively) compared to low ascorbate supplemented mice (5.6 ± 0.7 and 11.0 ± 4.6 pg/μg DNA in B16-F10 and LL/2, respectively, both P < 0.05 using t-test).