It has been shown that PDCD10 interacts in vitro with the other two proteins involved in genesis of cavernomas: K-Rev interaction trapped 1 (KRIT1) and Malcavernin, which participates in CCM1-dependent modulation of β1-integrin-mediated signalling and CCM2-mediated p38 MAPK signalling in response to cellular stress [34]. The gene discussed is PDCD10; the disease is cavernous hemangioma.