Furthermore, we evaluated the association of eGFR as a continuous measure with different ABI categories and found a significant relation (β = –0.100; P = 0.043) after adjustment for age, sex, the history of hypertension, the duration of diabetes, complications including diabetic neuropathy and retinopathy, smoking status, BMI, triglyceride and C reactive protein levels. The gene discussed is CRP; the disease is diabetes mellitus.