Epigallocatechin and epigallocatechin gallate have been demonstrated in cell cultures and animal models of obesity to reduce adipocyte differentiation and proliferation, body weight, fat mass, plasma levels of TG, free fatty acids, cholesterol, glucose, and insulin, as well as to increase fat oxidation [36,37,38]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.