However, CACNG1, CACNB1 and CACNA2D1 encode for subunits of the DHPR calcium channel, which is in direct contact and regulating RYR1 in skeletal muscle, and one mutation in the channel subunit CACNA1S of DHPR was linked to malignant hyperthermia [43]. Here, CACNB1 is linked to Malignant hyperthermia.