However, CACNG1, CACNB1 and CACNA2D1 encode for subunits of the DHPR calcium channel, which is in direct contact and regulating RYR1 in skeletal muscle, and one mutation in the channel subunit CACNA1S of DHPR was linked to malignant hyperthermia [43]. The gene discussed is CACNA2D1; the disease is Malignant hyperthermia.