PGP and early-onset autosomal dominant Alzheimer disease: Given the biological targeting properties of 5b, the complex also may enable PET imaging of MDR in tumors [24], [33], [45], Pgp activity at the blood brain barrier in neurodegenerative diseases, such as Alzheimer’s disease and Parkinson disease [43], [46], as well as detection of mitochondrial myopathies in vivo[47].