LRIG2 and squamous cell carcinoma: This mirrors to some extent the situation in oligodendrogliomas [20] and early-stage squamous cell carcinoma of the uterine cervix [21], where high expression of LRIG2 is associated with poor survival, whereas LRIG1 expression negatively correlates with tumor grade [10], [11], [12] and associates with better survival in numerous tumors [11], [12], indicating that the functions of LRIG2 and LRIG1 may be different in the progression of tumors.