In the present study, we for the first time demonstrated that the soluble LRIG2 ectodomain was capable of being released from glioblastoma cells and soluble LRIG2 ectodomain promoted the proliferation and inhibited the apoptosis of glioblastoma cells in vitro and in vivo in a similar manner to the full-length LRIG2, which suggested that LRIG2 ectodomain played a similar role to the full-length LRIG2 in the progression of glioblastoma. The gene discussed is LRIG2; the disease is glioblastoma.