The herein present function of LRIG2 ectodomain in progression of glioblastoma was opposite to the full-length LRIG1 [18], [26] and LRIG1 ectodomain [14], [30], while in line with full-length LRIG2, which leads to the proposal that LRIG2 ectodomain may contribute to the function difference of the full-length LRIG2 and full-length LRIG1 in glioblastoma progression. Here, LRIG1 is linked to glioblastoma.