Congruently, it is recently reported that, by using an animal model of PDGF-induced glioma, the Lrig2E12−/− mice showed increased spontaneous mortality, reduced growth rate and protection against PDGFB-induced glioma and Lrig2E12+/+ mice developed gliomas at a higher frequency and of higher malignancy than Lrig2E12−/− mice, which indicated a pro-tumoregenic role of Lrig2 in the progression of oligodentroglioma. The gene discussed is PDGFB; the disease is central nervous system cancer.