LRIG2 and glioblastoma: Based on our finding that soluble LRIG2 ectodomain is capable of being released from full-length LRIG2, it is reasonable to speculate that the soluble LRIG2 ectodomain can release from the glioblastoma cells as an effective pro-growth factor in the microenvironment, interact with EGFR in an autocrine or paracrine way and enhance the EGFR signaling to promote the growth of glioblastoma.