Both full-length LRIG2 and LRIG2 ectodomain potently promote the proliferation and inhibited the apoptosis of glioblastoma cells in vitro and in vivo through physically interacting with EGFR, stabilizing EGFR, and enhancing EGFR activation and its downstream PI3 K/Akt pathway. This evidence concerns the gene EGFR and glioblastoma.