In the present study, we revealed that the expression levels of LRIG2 transcript in glioblastomas and LRIG2 protein in HGGs were both significantly higher compared to that in LGGs and we for the first time demonstrated that LRIG2 expression levels positively correlated with the grade of glioma, which predicted that LRIG2 might serve as a negative prognostic factor associated with poor glioblastoma survival. The gene discussed is LRIG2; the disease is central nervous system cancer.