To observe the effects of LRIG2 and LRIG2 ectodomain overexpression on glioblastoma growth in vitro and in vivo and elucidate the underlying mechanisms, we subcloned a human full-length LRIG2 cDNA and LRIG2 ectodomain cDNA into pLVX-puro-3×FLAG mammalian expression vectors respectively and transduced stably into U87 and U251 glioblastoma cells with pLVX-puro as the control vector. The gene discussed is LRIG2; the disease is glioblastoma.