Based on our finding that soluble LRIG2 ectodomain is capable of being released from full-length LRIG2, it is reasonable to speculate that the soluble LRIG2 ectodomain can release from the glioblastoma cells as an effective pro-growth factor in the microenvironment, interact with EGFR in an autocrine or paracrine way and enhance the EGFR signaling to promote the growth of glioblastoma. This evidence concerns the gene EGFR and glioblastoma.