[19]. Collectively, data to date suggest that LRIG2 in human and Lrig2 in mouse both play critical roles in the genesis and progression of glioma. In previous study, we demonstrated that LRIG1 inhibited the proliferation and promoted the apoptosis of glioblastoma cells in vitro and in vivo[18], [26], suggesting that LRIG1 exerts as a tumor suppressor in glioblastoma, which is in contrast to the results of LRIG2 herein presented. This evidence concerns the gene LRIG1 and central nervous system cancer.