In addition to TGFβ and KRAS activation, epidermal growth factor receptor (EGFR) signaling, a cascade aberrantly activated in the majority of PDACs, has been demonstrated to play a critical role in HH/GLI1-regulated tumor-initiating pancreatic cancer cells (Eberlet al., 2012). The gene discussed is TGFB1; the disease is pancreatic neoplasm.