To reveal the epigenetic status of AATK in human cancers in more detail, we have analyzed the aberrant methylation of AATK in lung cancer (A549, A427, H322, H358, HTB-171), breast cancer (MCF-7, ZR75-1), melanoma (Sk-Mel13, IGR1), leiomyosarcoma (LMS6/93), follicular thyroid (FTC133), larynx cancer (HEP2), pancreas carcinoma cell line (PaCa2), cervix cancer (HeLa), HEK293 and human fibroblast (HF-55) by COBRA (Fig. 1B). The gene discussed is AATK; the disease is familial pancreatic carcinoma.