We showed previously that TMEPAI knockdown in MDA-MB-231 cells markedly decreased the size of tumor xenografts compared to corresponding cells with control shRNA[7], which is consistent with an important role for TMEPAI in TGF-β dependent growth not only in culture[7] (Fig. 1D), but also in vivo [7]. This evidence concerns the gene TGFB1 and neoplasm.