Furthermore, Belin de Chantemelle and colleagues showed that plasma aldosterone levels are increased in obese mice and further increase with sustained leptin infusion, and the chronic α1-adrenergic receptor antagonism with prazosin blunted obesity-induced increased aldosterone levels and also abolished leptin-stimulated aldosterone secretion in obese mice [53]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.