We recently demonstrated that glomerular ABCA1 expression is decreased in patients with type 2 diabetes (T2D) and early DKD and in human podocytes treated with the sera from patients with type 1 diabetes (T1D) and DKD in the absence of changes in LDLR and HMGCR expression (52). The gene discussed is LDLR; the disease is type 2 diabetes mellitus.