Further, decreased ApoE expression in glomerular podocytes is observed in Tg26 (human immunodeficiency virus, HIV) and Nef (negative regulatory factor) transgenic mice, two models of HIV-associated nephropathy (HIVAN) (73), whereas increased ApoE and ApoB expression was found in association with accumulation of oil red O positive lipid droplets in glomerular visceral epithelial cells and mesangial cells in rats with puromycin aminonucleoside or adriamycin induced nephrosis (74). The gene discussed is APOE; the disease is HIV-associated nephropathy.