APOE and lipoprotein glomerulopathy: In a different study, in which the APOE-Sendai mutation (Arg145Pro mutation found in patients with LPG) was introduced into ApoE−/− mice showed that, although similar, the LPG-like lesions observed in the APOE-Sendai mice were different from the lesions in aged ApoE−/− mice (65, 67) indicating that APOE variants may contribute to a differential phenotype in LPG.