Likewise, renal cholesterol accumulation in high fat/sucrose-fed (116) (type 2 diabetes model for DKD) and STZ-induced rats (type 1 diabetes model for DKD) was associated with increased expression of SCAP, SREBP-2, HMGCR, and LDLR. The gene discussed is HMGCR; the disease is type 1 diabetes mellitus.