Constitutive ApoE−/− mice generated through partial replacement of exon 3 and part of intron 3 of the ApoE gene by a neomycin cassette (63) are a model for experimental atherosclerosis and develop a renal phenotype similar to that observed in patients with type III hyperlipoproteinemia and LPG (64–66). Here, APOE is linked to hyperlipoproteinemia.