Patients with LPG have proteinuria and nephrotic syndrome with elevated serum APOE levels, abnormal lipoprotein deposition in glomerular capillaries in form of laminated thrombi that contain APOB and APOE, a variable degree of mesangial proliferation, and dysbetalipoproteinemia (55, 56). The gene discussed is APOE; the disease is hyperlipoproteinemia type 3.