INS and Hyperglycemia: KsJ mice showed significant hyperglycemia from day 4 that reached a modestly diabetic plateau by day 12 (Figure 4A), had reduced islet insulin staining (Figure 4B) and increased islet macrophage numbers, whereas MIP-HSD1tg/+ mice maintained normal glycemia and pancreatic morphology and displayed abrogated macrophage infiltration (Figure 4C, and quantification, Figure 4D).