Importantly, several genetic studies have associated mutations or polymorphisms in the CART gene in humans with obesity, clearly demonstrating a crucial role of CART in the control of energy homeostasis also in humans (Hager et al., 1998; Challis et al., 2000; del Giudice et al., 2001; Yamada et al., 2002; Dominguez et al., 2004a; Guerardel et al., 2005; Yanik et al., 2006; Rigoli et al., 2010). The gene discussed is CARTPT; the disease is Obesity.