CARTPT and obesity due to melanocortin 4 receptor deficiency: Despite a lack of correlation or consistent association with obesity through systematic mutational analysis (Lambert et al., 1998; Challis et al., 2000; Okumura et al., 2000; Rogge et al., 2008), a particular genetic variant 1475A>G among the polymorphisms was illustrated to significantly affect waist-to-hip ratio as well as the levels of plasma insulin and triglycerides (Challis et al., 2000), suggesting a putative pivotal role of CART in glucose- and lipid-homeostasis.