Investigation in a large Caucasian population of approximately 1000 subjects in the United Kingdom identified two common polymorphisms in the 3′-untranslated region of CART, that were implicated to interfere with fat distribution and contribute to dyslipidaemia (Challis et al., 2000; Rogge et al., 2008) (Table 3). Here, CARTPT is linked to inherited lipid metabolism disorder.