This relationship between leptin and CART levels was less consistently demonstrated at the PVN and LHA (Wortley et al., 2004), despite evidence supporting a pivotal role of CART-containing neurons projecting from the Arc to the second order neurons located in the PVN and LHA in producing anorexia (Elias et al., 1999; Wang et al., 2000; Fekete et al., 2004). The gene discussed is ARC; the disease is Anorexia.