Although gelsolin is considered as a tumor suppressor in many types of malignancies, e.g., breast, bladder, colon, gastric, kidney, lung, oral, ovarian, pancreatic, and prostate cancers (reviewed by Li with colleagues (Li et al. 2012)), there is very little known about gelsolin in CNS and PNS tumors. This evidence concerns the gene GSN and paraneoplastic neurologic syndrome.