MMP14 and pancreatic neoplasm: MT1-MMP also known as MMP-14 has been described as MMP with anticancer effects [145], but two in vivo studies showed that overexpression of MT1-MMP-induced remodeling of the ECM and mammary gland adenocarcinoma formation [81]; in pancreatic cancer, the MT1-MMP overexpression was seen to affect cancer development [134].