The various transgenic and mutation mouse models of cancer were used: models of pancreatic carcinoma—Rip1-Tag2 [131], Kras [134], Myc-BclXl [135]; model of cervical cancer—HPV/E2 [88]; model of prostate cancer—CR2-Tag [136]; model of colon cancer—cis-Apc/Smad4 [94]; model of squamous cell carcinoma—HPV16 [143]; model of intestinal neoplasia—Min/Apc [95]; and models of mammary cancer—MMTV [12, 68, 81], MMTV-PyVT [80], and MMTV-ras [86]. The gene discussed is APC; the disease is cervical carcinoma.