With the strict threshold of RMA signals that were upregulated at least 4-fold and 2-fold compared with normal brain tissue and OD respectively, a total of 6 highly expressed genes were identified in GBM, including AFF2, GNAL, ARPP21, CACNA2D3, HIST1H3A~HIST1H3J, and RGS7 (Table I). The gene discussed is ARPP21; the disease is glioblastoma.