EMA and TTG IgA antibodies present high sensitivity (97-90%) and specificity (99-95%) for the serological diagnosis of celiac disease.5 It is well recognized that the combined use of the two antibodies (EMA and TTG) provides greater sensitivity in diagnosing celiac disease, since almost one third of the patients present reactivity for only one of the two antibodies.23 However, from a practical standpoint, the sensitivity of commercial assays may vary and does not necessarily represent what is described in the literature, especially in subjects with major villous atrophy.24 This evidence concerns the gene CD79A and celiac disease.