AKR1B1 and colonic neoplasm: In the continuous assessing its bioactivity and finding more active agents, the anti-diabetic complications and anti-cancer activity of all fractions of alcohol extracts of kernels (CK), shells (CS) and involucres (CI) were evaluated on human recombinant aldose reductase (HR-AR) assay, advanced glycation end products (AGEs) formation assay and human COLO 320 DM colon cancer cells inhibitory assay in the present work, respectively.