In the continuous assessing its bioactivity and finding more active agents, the anti-diabetic complications and anti-cancer activity of all fractions of alcohol extracts of kernels (CK), shells (CS) and involucres (CI) were evaluated on human recombinant aldose reductase (HR-AR) assay, advanced glycation end products (AGEs) formation assay and human COLO 320 DM colon cancer cells inhibitory assay in the present work, respectively. This evidence concerns the gene AR and colonic neoplasm.