HPSE2 and digestive system carcinoma: The results clearly demonstrated that patients with different types of gastrointestinal carcinomas were older and presented higher expression of heparanase isoforms (heparanase-1 50 kDa: R = 0.658 and P < 0.0001; heparanase-1 65 kDa: R = 0.380 and P = 0.002; heparanase-2: R = 0.345 and P = 0.005), in comparison with the donor group (control).