Clinical feature correlations demonstrated that there was no significant difference between heparanase-1 (50 kDa), heparanase-1 (65 kDa) or heparanase-2 expression and tumor differentiation, tumor metastasis, tumor vascular invasion, lymphatic invasion or perineural infiltration, as observed through statistical analysis (data not shown). The gene discussed is HPSE2; the disease is neoplasm.