The statistical parameters obtained through logistic regression proved that each heparanase isoform expression was straightforwardly dependent on the tumor [heparanase-1 (50 kDa): P < 0.0001; heparanase-1 (65 kDa): P = 0.002; and heparanase-2: P < 0.0001] and was independent of the patient’s age [heparanase-1 (50 kDa): P = 0.270; heparanase-1 (65 kDa): P = 0.218; and heparanase-2: P = 0.717]. This evidence concerns the gene HPSE and neoplasm.