The active form of heparanase-1 (50 kDa) presented higher protein expression in the gastrointestinal carcinoma patients than in the control group: respectively, 28.87 ± 9.70 pixels/μg of total protein and 12.06 ± 4.85 pixels/μg of total protein. The gene discussed is HPSE; the disease is digestive system carcinoma.