Thus, the data shown here certainly contribute towards shedding some light on the physiopathology of CIN, in which HLA-G expression in cervical cells may act in conjunction with other factors, such as immunosuppression induced by HPV infection, thereby resulting in the more severe cervical disease observed in CIN III and cervical cancer patients. The gene discussed is HLA-G; the disease is uterine cervix carcinoma in situ.