MDM2 and neoplasm: Regions amplified by BFB cycles in the discovery cohort harbour oncogenes or genes that promote tumour growth such as RCF3, MDM2, VEGFA, BCAT1 and KRAS. Tumours with complex localized SVs in their genomes showed higher prevalence of inversions and deletions (P<0.05, t-test), with breakpoints presenting a high incidence of microhomology, suggesting microhomology-mediated break repair and/or non-homologous recombination as the major mechanism of DNA repair (Supplementary Fig. 9).