CCN1 and rheumatoid arthritis: The proliferative rates of RA-FLS cells transfected with siRNA were 74.3±0.9 and 56.2±7.4% those of RA-FLS cells transfected with control siRNA at five and seven days respectively, suggesting that the RA-FLS cell proliferative ability was significantly impaired by the introduction of Cyr61-siRNA.