For example, it has been shown that sirtuin-1/FoxO3a signaling is crucial for the induction of Cyr61 expression in RA synovial fibroblasts (8), and also that p53 is involved in the post-transcriptional regulation of Cyr61 expression via microRNA-22 (miR-22) (9). The gene discussed is CCN1; the disease is rheumatoid arthritis.