Western blot study showed that the S-5s could inhibit NF-κB activation only, while the R-5s could inhibit both p53-MDM2 interaction and induce the inhibition of NF-κB activation with the in vitro antiproliferative result indicating poor selectivity over cancer cell lines (H1299 and Saos-2) with deleted p53. This evidence concerns the gene NFKB1 and cancer.