They used antibodies against MCAM and examined their effect on tumor growth, angiogenesis and metastasis formation.18,19 In the study, where an ABX-MA1 antibody was used, an approximately threefold reduction in tumor growth and approximately fivefold lower number of metastases in the lungs compared to the control group were demonstrated.19 The obtained antitumor effect was, in contrast to our predictions, not attributed to the inhibition of cell proliferation, since in vitro testing on the ABX-MA1 antibody failed to prove that. This evidence concerns the gene PNMA1 and neoplasm.