MCAM and melanoma: In one study, where the migration of cells was affected for 50%, gene electrotransfer was used for the delivery of siRNA against MCAM into human melanoma cells.23Mcam silencing by siRNA after lipofection also reduced the migration of HUVEC and breast cancer cells for 70 and 40%, respectively.22,25 The studies, where antibodies against MCAM were used, demonstrated a reduction of migration only in HUVEC, where it was 75%.18,45