For example, comparisons between the response of Nramp-Tg and Sv129S6 mice to chronic Salmonella infection showed that Nramp-Tg mice experience more severe inflammatory disease than Sv129S6 mice, with higher levels of proinflammatory serum cytokines (IFNγ, TNFα, IL-1β and IL-2) and chemokines (MCP-1 and CXCL1) and decreased anti-inflammatory cytokines (IL-10 and IL-4)[27]. The gene discussed is TNF; the disease is Salmonella Infections.