To determine whether congenic expression of Nramp1G169 confers resistance to acute Salmonella infection, C57BL/6, Nramp-Cg, Nramp-Tg and 129×1/SvJ mice were challenged IP with virulent Salmonella strain SL1344 and bacterial colonization was measured in relevant organs (spleen and liver) 3 days later. This evidence concerns the gene SLC11A1 and Salmonella Infections.