To further explore the role of genetic variants in the IFN signaling pathway genes in CRC, we genotyped a set of potentially functional SNPs in the IRF3, IRF5, IRF7, IFNA, IFNB, IFNE, IFNK, IFNW, IFNG, IFNAR1, IFNAR2, IFNGR1 and IFNGR2 genes in a case-control study of 1327 CRC patients and 758 healthy controls from the Czech Republic and evaluated their association with CRC susceptibility, progression, and prognosis. The gene discussed is IFNG; the disease is colorectal carcinoma.