To further explore the role of genetic variants in the IFN signaling pathway genes in CRC, we genotyped a set of potentially functional SNPs in the IRF3, IRF5, IRF7, IFNA, IFNB, IFNE, IFNK, IFNW, IFNG, IFNAR1, IFNAR2, IFNGR1 and IFNGR2 genes in a case-control study of 1327 CRC patients and 758 healthy controls from the Czech Republic and evaluated their association with CRC susceptibility, progression, and prognosis. This evidence concerns the gene IFNK and colorectal carcinoma.