TP53 and neoplasm: In the present work [dichloro(2-acetylpyridineacetyl-hydrazone)copper(II)], [Cu(H2AcMe)Cl2] (1) and [dichloro(2-benzoylpyridineacetylhydrazone)copper(II)], [Cu(H2BzMe)Cl2] (2) were studied for their cytotoxic activities against U87 (p53 wild-type glioblastoma multiforme) and T98 (p53 mutant glioblastoma multiforme) tumor cells.