In addition, as a selective p38 MAPK inhibitor readily abolished the PODX-elevated soluble β-cat level without significantly altering the expression of PODX and β-cat, it indicates that PODX elevates the soluble β-cat level/β-cat signaling in a post-translational p38 MAPK-dependent manner in GBM cells. This evidence concerns the gene CAT and glioblastoma.