Because of this, the complex anti‐diabetic regimen and polypharmacy, often applied to patients with a long disease duration and with multiple risk factors, can be associated with unwanted side‐effects including hypoglycemia and weight gain.17, 30 In our cohort, one‐fifth of patients with probable depression were treated with insulin, which might be associated with social stigma and met with resistance due to pain, inconvenience and interference with daily life.31 This evidence concerns the gene INS and major depressive disorder.