BCL6 and diffuse large B-cell lymphoma: Subsequent cytogenetic and molecular descriptions of t(3;8)(q27;q24) have been in DLBCL cases with more complex karyotypes including t(14;18)(q32;q23) “triple hit” cases [18–22]; DNA sequence analysis has shown direct juxtaposition of sequences from chromosome 3q27 with those from chromosome 8q24 with no intervening IG sequences; the BCL6 breakpoints fell outside the BCL6 major translocation cluster (MTC).